The Scripps Research Institute - Alcohol Research Center is dedicated to exploring the complexities of alcohol use disorder (AUD) through its five Research Components—Functional Connectomics, Molecular, Neuropharmacology, Neurophysiology, and Neurocircuitry—and three supporting Cores: the Administrative Core, Animal Models Core, and Dissemination Core. Each component employs cutting-edge techniques to investigate how chronic alcohol exposure alters brain function and connectivity, assesses the role of specific brain receptors in addiction behaviors, and identifies neurochemical changes that may lead to compulsive drinking. The collaborative environment at TSRI-ARC not only advances scientific understanding but also aims to translate findings into practical treatments, ultimately improving outcomes for individuals struggling with AUD. Through community engagement, the center ensures that its research has a meaningful impact beyond the laboratory, making significant strides toward understanding and combating addiction.