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Use single-cell whole-brain imaging of immediate-early genes to identify the network mechanisms associated with pharmacological interventions and circuit-specific interventions that decrease addiction-like behaviors during abstinence

Provide further knowledge of the neuroadaptations within the infralimbic cortex due to alcohol dependence with a focus on the hypocretin (Hcrt), dynorphin (Dyn) and corticotropin-releasing factor (CRF) transmission



Probe the relevance of astrocytic metabotropic glutamate receptor 3 as an important regulator of glutamate homeostasis in the medial prefrontal cortex that can be targeted to reduce excessive alcohol drinking

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