Publications since January 1, 2018




Agoglia AE, Zhu M, Ying R, Sidhu H, Natividad LA, Wolfe SA, Buczynski MW, Contet C, Parsons LH, Roberto M, Herman MA. Corticotropin-releasing factor receptor-1 neurons in the lateral amygdala display selective sensitivity to acute and chronic ethanol exposure. eNeuro 2020;7(2):ENEURO.0420-19.2020. PMC7059189

Khom S, Steinkellner T, Hnasko TS, Roberto M. Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala. Sci Adv 2020;6:eaaz1050. PMC7080445

Kim JS, Martin-Fardon R. Possible role of CRF-Hcrt interaction in the infralimbic cortex in the emergence and maintenance of compulsive alcohol-seeking behavior. Alcohol Clin Exp Res 2020;44:354-367. PMC7018591

Kirson D, Oleata CS, Roberto M. Taurine suppression of central amygdala GABAergic inhibitory signaling via glycine receptors is disrupted in alcohol dependence. Alcohol Clin Exp Res 2020;44:445-454. PMC7018558

Matzeu A, Martin-Fardon R. Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats. Neuropharmacology 2020;164:107906. PMC6954966

Matzeu A, Martin-Fardon R. Targeting the orexin system for prescription opioid use disorder. Brain Sci 2020;10(4):226. PMC7225970

Varodayan FP, Minnig MA, Steinman MQ, Oleata CS, Riley MW, Sabino V, Roberto M. PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology 2020;168:107752. PMC7048635




Bajo M, Patel RR, Hedges DM, Varodayan FP, Vlkolinsky R, Davis TD, Burkart MD, Blednov YA, Roberto M. Role of MyD88 in IL-1β and ethanol modulation of GABAergic transmission in the central amygdala. Brain Sci 2019;9(12):E361

de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun  2019;10:1238. PMC6423296

Goulding SP, de Guglielmo G, Carrette LLG, George O, Contet C. Systemic administration of the cyclin-dependent kinase inhibitor (S)-CR8 selectively reduces escalated ethanol intake in dependent rats. Alcohol Clin Exp Res 2019;43:2079-2089. PMC6779498

Jimenez VA, Herman MA, Cuzon Carlson VC, Walter NA, Grant KA, Roberto M. Synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys. Neuropsychopharmacology 2019;44:982-993. PMC6461779

Matzeu A, Martin-Fardon R. Orexin and cocaine addiction. In: Fadel JR, Burk JA (eds) The Orexin/Hypocretin System: Functional Roles and Its Therapeutic Potential. Academic Press, London, 2019, pp. 121-137

Patel RR, Khom S, Steinman MQ, Varodayan FP, Kiosses WB, Hedges DM, Vlkolinsky R, Nadav T, Polis I, Bajo M, Roberts AJ, Roberto M. IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala. Brain Behav Immun 2019;75:208-219. PMC6383367

Pavón FJ, Serrano A, Stouffer DG, Polis I, Roberto M, Cravatt BF, Martin-Fardon R, Rodríguez de Fonseca F, Parsons LH. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice. Addict Biol 2019;24:1204-1215. PMC6551299


Suarez J, Khom S, Alen F, Natividad LA, Varodayan FP, Patel RR, Kirson D, Arco R, Ballesta A, Bajo M, Rubio L, Martin-Fardon R, Rodriguez de Fonseca F, Roberto M. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addict Biol 2019; doi: 10.1111/adb.12813

Tunstall BJ, Kirson D, Zallar L, Vendruscolo JCM, Ho CP, Lee MR, Leggio L, Koob GF, Roberto M., Vendruscolo LF. Oxytocin blocks compulsive-like alcohol drinking and blocks alcohol effects on GABAergic transmission in the central nucleus of the amygdala. PLoS Biol 2019;17:e2006421. PMC6467366

Wolfe SA, Sidhu H, Patel RR, Kreifeldt M, D'Ambrosio SR, Contet C, Roberto M. Molecular, morphological, and functional characterization of corticotropin-releasing factor receptor 1-expressing neurons in the centralnucleus of the amygdala. eNeuro 2019;6: ENEURO.0087-19.2019. PMC6584068

Zorrilla EP, Koob GF. Impulsivity Derived From the Dark Side: Neurocircuits that contribute to negative urgency. Front Behav Neurosci 2019;13:136 [corrigendum: 13:188]. PMC6603097

Zorrilla EP, Koob GF. The dark side of compulsive eating and food addiction: affective dysregulation, negative reinforcement, and negative urgency. In: Cottone P, Sabino V, Moore CF, Koob GF (eds) Compulsive Eating Behavior and Food Addiction: Emerging Pathological Constructs, Academic Press, New York, 2019, pp. 115-192.




Blasio A, Wang J, Wang D, Varodayan FP, Pomrenze MB, Miller J, Lee AM, McMahon T, Gyawali S, Wang HY, Roberto M, McHardy S, Pleiss MA, Messing RO. Novel small- molecule inhibitors of protein kinase C epsilon reduce ethanol consumption in mice. Biol Psychiatry 2018;84:193-201. PMC5984071 

de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O. Inhibition of glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. Pharmacol Biochem Behav 2018;167:36-41. PMC5866249 

Kirson D, Oleata CS, Parsons LH, Ciccocioppo R, Roberto M. CB1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats. Addict Biol 2018;23:676-688. PMC5745318 

Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O. Systemic and intra-habenular activation of the orphan G protein-coupled receptor GPR139 decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rats. eNeuro 2018;5:ENEURO.0153-18.2018. PMC6027959

Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O. Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep 2018;8:13893. PMC6141462

Kreisler AD, Mattock M, Zorrilla EP. The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats. Appetite 2018;130:59-69. PMC6168430

Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP. Evaluation of alcohol preference and drinking in msP rats bearing a Crhr1 promoter polymorphism. Front Psychiatry 2018;9:28. PMC5818434

Mason BJ, Quello S, Shadan F. Gabapentin for the treatment of alcohol use disorder. Expert Opin Investig Drugs 2018;27:113-124. PMC5957503

Mason BJ. Pharmacological treatment of alcohol use disorders. In: Evans SM (ed) APA Handbook of Psychopharmacology. American Psychological Association, Washington DC, 2018, pp. 481-505

Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R. Dynorphin counteracts orexin in the paraventricular nucleus of the thalamus: cellular and behavioral evidence. Neuropsychopharmacology 2018;43:1010-1020. PMC5854806

Matzeu A, Martin-Fardon R. Drug seeking and relapse: new evidence of a role for orexin and dynorphin co-transmission in the paraventricular nucleus of the thalamus. Front Neurol 2018;9:720. PMC6121102 

Matzeu A, Schmeichel BE, Koebel P, Vendruscolo LF, Kieffer BL, Koob GF, Contet C, Martin-Fardon R. Knockdown of hypocretin attenuates extended-access cocaine self-administration in rats. Neuropsychopharmacology 2018;43:2373-2382. PMC6180106

Matzeu A, Terenius L, Martin-Fardon R. Exploring sex differences in the attenuation of ethanol drinking by naltrexone in dependent rats during early and protracted abstinence. Alcohol Clin Exp Res 2018;42:2466-2478. PMC6286204

McClatchy DB, Yu NK, Martínez-Bartolomé S, Patel R, Pelletier AR, Lavalle-Adam M, Powell SB, Roberto M, Yates JR. Structural analysis of hippocampal kinase signal transduction. ACS Chem Neurosci 2018;9):3072-3085. PMC6374210

Natividad LA, Steinman MQ, Laredo SA, Irimia C, Polis I, Lintz R, Buczynski MW, Martin-Fardon R, Roberto M, Parsons LH. Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility. Addict Biol 2018;23:1117-1129. PMC5862723

Pavon FJ, Serrano A, Sidhpura N, Polis I, Stouffer D, de Fonseca FR, Cravatt BF, Martin-Fardon R, Parsons LH. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addict Biol 2018;23:723-734. PMC5747548 

Roberto M, Patel RR, Bajo M. Ethanol and cytokines in the central nervous system. Handb Exp Pharmacol 2018;248:397-431

Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. Neuropsychopharmacology 2018;43:2373-2382. PMC6180106

Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. Neuropsychopharmacology 2018;43:1840-1850. PMC6046053 

Sidhu H, Kreifeldt M, Contet C. Affective disturbances during withdrawal from chronic intermittent ethanol inhalation in C57BL/6J and DBA/2J male mice. Alcohol Clin Exp Res 2018;42:1281-1290. PMC6028290

Spierling SR, Kreisler AD, Williams CA, Fang SY, Pucci SN, Kines KT, Zorrilla EP. Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: sex differences and individual vulnerability. Physiol Behav 2018;192:3-16. PMC6019212

Varodayan FP, Khom S, Patel R, Hedges D, Steinman MQ, Oleata CS, Roberto M, Bajo M. Role of TLR4 in the modulation of central amygdala GABA transmission by CRF following restraint stress. Alcohol Alcohol 2018;53:642-649. PMC6203127

Varodayan FP, Sidhu H, Kreifeldt M, Roberto M, Contet C. Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal. Neuropharmacology 2018;133:470-480. PMC5865397 


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