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Publications since January 1, 2018


Blasio A, Wang J, Wang D, Varodayan FP, Pomrenze MB, Miller J, Lee AM, McMahon T, Gyawali S, Wang HY, Roberto M, McHardy S, Pleiss MA, Messing RO. Novel small- molecule inhibitors of protein kinase C epsilon reduce ethanol consumption in mice. Biol Psychiatry 2018;84(3):193-201. PMC5984071 ​

de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O. Inhibition of glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. Pharmacol Biochem Behav 2018;167:36-41. PMC5866249 

de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun 2019;10(1):1238. PMC6423296

Jimenez VA, Herman MA, Cuzon Carlson VC, Walter NA, Grant KA, Roberto M. Synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys. Neuropsychopharmacology 2019;44(5):982-993.

Kirson D, Oleata CS, Parsons LH, Ciccocioppo R, Roberto M. CB1and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats. Addict Biol 2018;23(2):676-688. PMC5745318 

Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O. Systemic and intra-habenular activation of the orphan G protein-coupled receptor  GPR139 decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rats. eNeuro 2018;5(3):ENEURO.0153-18.2018. PMC6027959

Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O. Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep 2018;8(1):13893. PMC6141462

Kreisler AD, Mattock M, Zorrilla EP. The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats. Appetite 2018;130:59-69. PMC6168430 


Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP. Evaluation of alcohol preference and drinking in msP rats bearing a Crhr1promoter polymorphism. Front Psychiatry 2018;9:28. PMC5818434

Mason BJ, Quello S, Shadan F. Gabapentin for the treatment of alcohol use disorder. Expert Opin Investig Drugs 2018;27(1):113-124. PMC5957503

Mason BJ. APA Handbook of Psychopharmacology. in press ed. Evans SM, editor. Washington DC. American Psychological Association; 2018. Pharmacological Treatment of Alcohol Use Disorders.


Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R. Dynorphin counteracts orexin in the paraventricular nucleus of the thalamus: cellular and behavioral evidence. Neuropsychopharmacology 2018;43(5):1010-1020. PMC5854806

Matzeu A, Martin-Fardon R. Drug seeking and relapse: new evidence of a role for orexin and dynorphin co-transmission in the paraventricular nucleus of the thalamus. Front Neurol 2018;9:720. PMC6121102 

Matzeu A, Martin-Fardon R. Orexin and cocaine addiction. In: Fadel JR, Burk JA (Eds.),The Orexin/Hypocretin System: Functional Roles and Its Therapeutic Potential,Academic Press, London; 2019:121-137.

MatzeuA, Schmeichel BE, Koebel P, Vendruscolo LF, Kieffer BL, Koob GF, Contet C, Martin-Fardon R. Knockdown of hypocretin attenuates extended-access cocaine self-administration in rats. Neuropsychopharmacology 2018;43:2373-2382. PMC6180106

Matzeu A, Terenius L, Martin-Fardon R. Exploring sex differences in the attenuation of ethanol drinking by naltrexone in dependent rats during early and protracted abstinence. Alcohol Clin Exp Res 2018;42(12):2466-2478. PMC6286204

McClatchy DB, Yu NK, Martínez-Bartolomé S, Patel R, Pelletier AR, Lavalle-AdamM, Powell SB, Roberto M, Yates JR. Structural analysis of hippocampal kinasesignal transduction. ACS Chem Neurosci 2018;9(12):3072-3085. PMC6374210

Natividad LA, Steinman MQ, Laredo SA, Irimia C, Polis I, Lintz R, Buczynski MW, Martin-Fardon R, Roberto M, Parsons LH. Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility. Addict Biol 2018;23:1117-1129. PMC5862723

Patel RR, Khom S, Steinman MQ, Varodayan FP, Kiosses WB, Hedges DM, Vlkolinsky R, Nadav T, Polis I, Bajo M, Roberts AJ, Roberto M. IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala. Brain Behav Immun 2019;75:208-219. PMC6383367

Pavon FJ, Serrano A, Sidhpura N, Polis I, Stouffer D, de Fonseca FR, Cravatt BF, Martin-Fardon R, Parsons LH. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addict Biol 2018;23(2):723-734. PMC5747548 

Pavón FJ, Serrano A, Stouffer DG, Polis I, Roberto M, Cravatt BF, Martin-Fardon R, Rodríguez de Fonseca F, Parsons LH. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice. Addict Biol 2018; doi: 10.1111/adb.12695. PMC6551299

Roberto M, Patel RR, Bajo M. Ethanol and cytokines in the central nervous system. Handb Exp Pharmacol 2018;248:397-431.

Roberto M, Spierling SR, Kirson D, Zorrilla EP. Corticotropin-releasing factor (CRF) and addictive behaviors. Int Rev Neurobiol 2017;136:5-51. PMC6155477 

Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. Neuropsychopharmacology 2018;43(12):2373-2382. PMC6180106

Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. Neuropsychopharmacology 2018;43(9):1840-1850. PMC6046053 

Sidhu H, Kreifeldt M, Contet C. Affective disturbances during withdrawal from chronic intermittent ethanol inhalation in C57BL/6J and DBA/2J male mice. Alcohol Clin Exp Res 2018;42(7):1281-1290. PMC6028290

Spierling SR, Kreisler AD, Williams CA, Fang SY, Pucci SN, Kines KT, Zorrilla EP. Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: sex differences and individual vulnerability. Physiol Behav 2018;192:3-16. PMC6019212

Suarez J, Khom S, Alen F, Natividad LA, Varodayan FP, Patel RR, Kirson D, Arco R, Ballesta A, Bajo M, Rubio L, Martin-Fardon R, Rodriguez de Fonseca F, Roberto M. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addiction Biology, 2019;in press.

Tunstall BJ, Kirson D, Zallar L, Vendruscolo JCM, Ho CP, Lee MR, Leggio L, Koob GF, Roberto M., Vendruscolo LF. Oxytocin blocks compulsive-like alcohol drinking and blocks alcohol effects on GABAergic transmission in the central nucleus of the amygdala. PLoS Biol 2019;17(4):e2006421. PMC6467366

Varodayan FP, Khom S, Patel R, Hedges D, Steinman MQ, Oleata CS, Roberto M, Bajo M. Role of TLR4 in the modulation of central amygdala GABA transmission by CRF following restraint stress. Alcohol Alcohol 2018;53(6):642-649. PMC6203127

Varodayan FP, Sidhu H, Kreifeldt M, Roberto M, Contet C. Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal. Neuropharmacology 2018;133:470- 480. PMC5865397 

Wolfe SA, Sidhu H, Patel RR, Kreifeldt M, D'Ambrosio SR, Contet C, Roberto M. Molecular, morphological, and functional characterization of corticotropin-releasing factor receptor 1-expressing neurons in the central nucleus of the amygdala. eNeuro 2019; pii: ENEURO.0087-19.2019.

Zorrilla EP, Koob GF, Impulsivity derived from the dark side: neurocircuits that contribute to negative urgency. Front Behav Neurosci, in press.

Zorrilla EP, Koob GF. The dark side of compulsive eating and food addiction: affective dysregulation, negative reinforcement, and negative urgency. In: Cottone P, Sabino V, Koob GF, Moore C (eds), Compulsive Eating Behavior and Food Addiction: Emerging Pathological Constructs. Academic Press, in press.