AA006420

Publications since January 1, 2018

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In Press

Cruz B, Vozella V, Carper BA, Xu JC, Kirson D, Hirsch S, Nolen T, Bradley L, Fain K, Crawford M, Kosten TR, Zorrilla EP, Roberto M. FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder. Neuropsychopharmacology. 2022 Nov 18. doi: 10.1038/s41386-022-01497-w. Epub ahead of print. PMID: 36396784.

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Flores-Ramirez FJ, Varodayan FP, Patel RR, Illenberger JM, Di Ottavio F, Roberto M, Martin-Fardon R. Blockade of orexin receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol-seeking behavior in alcohol dependent rats. Br J Pharmacol. 2022 Dec 20. doi: 10.1111/bph.16015. Epub ahead of print. PMID: 36537731.

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Grigsby KB, Mangieri RA, Roberts AJ, Lopez MF, Firsick EJ, Townsley KG, Beneze A, Bess J, Eisenstein TK, Meissler JJ, Light JM, Miller J, Quello S, Shadan F, Skinner MH, Aziz HC, Metten P, Morissett RA, Crabbe JC, Roberto M, Becker HC, Mason BJ, Ozburn AR. Pre-clinical and clinical evidence for suppression of alcohol intake by apremilast. J Clin Invest. 2023 Jan 19:e159103. doi: 10.1172/JCI159103. Epub ahead of print. PMID: 36656645.

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Matzeu A, Martin-Fardon R. Orexin receptors as a treatment target for prescription opioid use disorder. In: Preedy VR and Patel VB (Eds.), Handbook of Substance Misuse and Addictions; From Biology to Public Health. Springer, Berlin (in press).

 

Okhuarobo A, Angelo M, Bolton JL, Lopez C, Igbe I, Baram TZ, Contet C. Influence of early-life adversity on responses to acute and chronic ethanol in female mice. Alcohol Clin Exp Res. 2022 Dec 3. doi: 10.1111/acer.14988. Epub ahead of print. PMID: 36462937.

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Zorrilla EP, Kreisler AD, Spierling S. Intermittent, extended access rodent models of compulsive eating, In: Avena N (ed) Animal Models of Eating Disorders (series title: Neuromethods, vol. 161). Springer, New York, in press.

 

2022

de Guglielmo G, Simpson S, Kimbrough A, Conlisk D, Baker R, Cantor M, Kallupi M, George O. Voluntary and forced exposure to ethanol vapor produces similar escalation of alcohol drinking but differential recruitment of brain regions related to stress, habit, and reward in male rats. Neuropharmacology 2022;222:109309.

 

Flores-Ramirez FJ, Illenberger JM, Pascasio GE, Matzeu A, Mason BJ, Martin-Fardon R. Alternative use of suvorexant (Belsomra®) for the prevention of alcohol drinking and seeking in rats with a history of alcohol dependence. Front Behav Neurosci 2022;16:1085882. PMC9813433.

 

Gutierrez A, Creehan KM, de Guglielmo G, Roberts AJ, Taffe MA. Behavioral effects of ethanol in the red swamp crayfish (Procambarus clarkii). J Exp Anal Behav 2022;117(3):472-492.

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Khom S, Rodriguez L, Gandhi P, Kirson D, Bajo M, Oleata CS, Vendruscolo LF, Mason BJ, Roberto M. Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats. Neurobiol Dis 2022;164:105610.

 

Kirson D, Spierling Bagsic SR, Murphy J, Chang H, Vlkolinsky R, Pucci SN, Prinzi J, Williams CA, Fang SY, Roberto M, Zorrilla EP. Decreased excitability of leptin-sensitive anterior insula pyramidal neurons in a rat model of compulsive food demand. Neuropharmacology 2022;208:108980.

 

Kreifeldt M, Herman MA, Sidhu H, Okhuarobo A, Macedo GC, Shahryari R, Gandhi PJ, Roberto M, Contet C. Central amygdala corticotropin-releasing factor neurons promote hyponeophagia but do not control alcohol drinking in mice. Mol Psychiatry 2022;27(5):2502-2513. PMC9149056.

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Patel RR, Varodayan FP, Herman MA, Jimenez V, Agnore R, Gao L, Bajo M, Cuzon Carlson VC, Walter NA, Fei SS, Grant KA, Roberto M. Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques. Neuropsychopharmacology 2022;47(4):847-856.

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Patel RR, Wolfe SA, Borgonetti V, Gandhi PJ, Rodriguez L, Snyder AE, D'Ambrosio S, Bajo M, Domissy A, Head S, Contet C, Dayne Mayfield R, Roberts AJ, Roberto M. Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol. Mol Psychiatry 2022;27(8):3441-3451. PMC9708587.

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Rodriguez L, Kirson D, Wolfe SA, Patel RR, Varodayan FP, Snyder AE, Gandhi PJ, Khom S, Vlkolinsky R, Bajo M, Roberto M. Alcohol dependence induces CRF sensitivity in female central amygdala GABA synapses. Int J Mol Sci 2022;23(14):7842. PMC9318832.

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Shah T, Dunning JL, Contet C. At the heart of the interoception network: Influence of the parasubthalamic nucleus on autonomic functions and motivated behaviors. Neuropharmacology 2022;204:108906.

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Varodayan FP, Patel RR, Matzeu A, Wolfe SA, Curley DE, Khom S, Gandhi PJ, Rodriguez L, Bajo M, D'Ambrosio S, Sun H, Kerr TM, Gonzales RA, Leggio L, Natividad LA, Haass-Koffler CL, Martin-Fardon R, Roberto M. The amygdala noradrenergic system is compromised with alcohol use disorder. Biol Psychiatry 2022;91:1008-1018. PMC9167785.

 

Wolfe SA, Vozella V, Roberto M. The synaptic interactions of alcohol and the endogenous cannabinoid system. Alcohol Res 2022;42(1):03. PMC8843413.

 

2021

Avchalumov Y, Kreisler AD, Xing N, Shayan AA, Bharadwaj T, Watson JR, Sibley B, Somkuwar SS, Trenet W, Olia S, Piña-Crespo JC, Roberto M, Mandyam CD. Sexually dimorphic prelimbic cortex mechanisms play a role in alcohol dependence: protection by endostatin. Neuropsychopharmacology 2021;46(11):1937-1949. PMC8429630

 

Avchalumov Y, Oliver RJ, Trenet W, Heyer Osorno RE, Sibley BD, Purohit DC, Contet C, Roberto M, Woodward JJ, Mandyam CD. Chronic ethanol exposure differentially alters neuronal function in the medial prefrontal cortex and dentate gyrus. Neuropharmacology 2021;185:108438. PMC7927349

 

Benvenuti F, Cannella N, Stopponi S, Soverchia L, Ubaldi M, Lunerti V, Vozella V, Cruz B, Roberto M, Ciccocioppo R. Effect of glucocorticoid receptor antagonism on alcohol self-administration in genetically-selected Marchigian Sardinian alcohol-preferring and non-preferring Wistar rats. Int J Mol Sci 2021;22:4184. PMC8073469

 

Khom S, Wolfe SA, Patel RR, Kirson D, Hedges DM, Varodayan FP, Bajo M, Roberto M. Alcohol dependence and withdrawal impair serotonergic regulation of GABA transmission in the rat central nucleus of the amygdala. J Neurosci 2020;40(36):6842-6853. PMC7470924

 

Kirson D, Khom S, Rodriguez L, Wolfe SA, Varodayan FP, Gandhi PJ, Patel RR, Vlkolinsky R, Bajo M, Roberto M. Sex differences in acute alcohol sensitivity of naïve and alcohol dependent central amygdala GABA synapses. Alcohol Alcohol 2021;56(5):581-588. PMC8406056

 

Kirson D, Steinman MQ, Wolfe SA, Spierling Bagsic SR, Bajo M, Sureshchandra S, Oleata CS, Messaoudi I, Zorrilla EP, Roberto M. Sex and context differences in the effects of trauma on comorbid alcohol use and post-traumatic stress phenotypes in actively drinking rats. J Neurosci Res 2021;99:3354-3372.

 

Kisby BR, Farris SP, McManus MM, Varodayan FP, Roberto M, Harris RA, Ponomarev I. Alcohol dependence in rats Is associated with global changes in gene expression in the central amygdala. Brain Sci 2021;11:1149. PMC8468792

 

Mason BJ. Medications to treat alcohol use disorder: targeting the dark side. Am J Psychiatry 2021;178:375-377.

 

Mason BJ, Heyser CJ. Alcohol use disorder: the role of medication in recovery. Alcohol Res 2021;41:7. PMC8184096

 

Matzeu A, Martin-Fardon R. Blockade of orexin receptors in the posterior paraventricular nucleus of the thalamus prevents stress-induced reinstatement of reward-seeking behavior in rats with a history of ethanol dependence. Front Integr Neurosci 2020;14:599710. PMC7683390

 

McGinn MA, Tunstall BJ, Schlosburg JE, Gregory-Flores A, George O, de Guglielmo G, Mason BJ, Hunt HJ, Koob GF, Vendruscolo LF. Glucocorticoid receptor modulators decrease alcohol self-administration in male rats. Neuropharmacology 2021;188:108510. PMC8099171

 

Natividad LA, Steinman MQ, McGinn MA, Sureshchandra S, Kerr TM, Ciccocioppo R, Messaoudi I, Edwards S, Roberto M. Impaired hypothalamic feedback dysregulates brain glucocorticoid signaling in genetically-selected Marchigian Sardinian alcohol-preferring rats. Addict Biol 2021;26(3):e12978. PMC8052265

 

Patel RR, Wolfe SA, Bajo M, Abeynaike S, Pahng A, Borgonetti V, D'Ambrosio S, Nikzad R, Edwards S, Paust S, Roberts AJ, Roberto M. IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake. Prog Neurobiol 2021;199:101952. PMC7925373

 

Pavón FJ, Polis IY, Stouffer DG, Cravatt BF, Roberto M, Martin-Fardon R, Rodríguez de Fonseca F, Parsons LH, Serrano A. Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex. Neurobiol Stress 2021;14:100293. PMC7809503

 

Roberto M, Kirson D, Khom S. The role of the central amygdala in alcohol dependence. Cold Spring Harb Perspect Med 2021;11:a039339. PMC7382982

 

Serafine KM, O'Dell LE, Zorrilla EP. Converging vulnerability factors for compulsive food and drug use. Neuropharmacology 2021;196:108556. PMC8445770

 

Shah T, Dunning JL, Contet C. At the heart of the interoception network: Influence of the parasubthalamic nucleus on autonomic functions and motivated behaviors. Neuropharmacology 2021;204:108906.

 

Simpson S, Chen Y, Wellmeyer E, Smith LC, Aragon Montes B, George O, Kimbrough A. The hidden brain: uncovering previously overlooked brain regions by employing novel preclinical unbiased network approaches. Front Syst Neurosci 2021;15:595507. PMC8097000

 

Staples MC, Herman MA, Lockner JW, Avchalumov Y, Kharidia KM, Janda KD, Roberto M, Mandyam CD. Isoxazole-9 reduces enhanced fear responses and retrieval in ethanol-dependent male rats. J Neurosci Res 2021;99:3047-3065.

 

Steinman MQ, Kirson D, Wolfe SA, Khom S, D'Ambrosio SR, Spierling Bagsic SR, Bajo M, Vlkolinský R, Hoang NK, Singhal A, Sureshchandra S, Oleata CS, Messaoudi I, Zorrilla EP, Roberto M. Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders. Mol Psychiatry 2021;26(7):3093-3107. PMC8058115

 

Suárez J, Khom S, Alén F, Natividad LA, Varodayan FP, Patel RR, Kirson D, Arco R, Ballesta A, Bajo M, Rubio L, Martin-Fardon R, Rodríguez de Fonseca F, Roberto M. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addict Biol 2020;25(5):e12813. PMC8050940

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Vozella V, Cruz B, Natividad LA, Benvenuti F, Cannella N, Edwards S, Zorrilla EP, Ciccocioppo R, Roberto M. Glucocorticoid receptor antagonist mifepristone does not alter innate anxiety-like behavior in genetically-selected Marchigian Sardinian (msP) rats. Int J Mol Sci 2021;22:3095. PMC8003048

 

2020

Agoglia AE, Zhu M, Ying R, Sidhu H, Natividad LA, Wolfe SA, Buczynski MW, Contet C, Parsons LH, Roberto M, Herman MA. Corticotropin-releasing factor receptor-1 neurons in the lateral amygdala display selective sensitivity to acute and chronic ethanol exposure. eNeuro 2020;7(2):ENEURO.0420-19.2020. PMC7059189

 

Cates HM, Benca-Bachman CE, de Guglielmo G, Schoenrock SA, Shu C, Kallupi M. National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies. Genes Brain Behav 2019;18:e12577. PMC7891887

 

Frank K, Abeynaike S, Nikzad R, Patel RR, Roberts AJ, Roberto M, Paust S. Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice. PLoS One 2020;15:e0239246. PMC7751976

 

Hedges DM, Yorgason JT, Brundage JN, Wadsworth HA, Williams B, Steffensen SC, Roberto M. Corticotropin releasing factor, but not alcohol, modulates norepinephrine release in the rat central nucleus of the amygdala. Neuropharmacology 2020;179:108293. PMC7572647

 

Khom S, Steinkellner T, Hnasko TS, Roberto M. Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala. Sci Adv 2020;6:eaaz1050. PMC7080445

 

Khom S, Wolfe SA, Patel RR, Kirson D, Hedges DM, Varodayan FP, Bajo M, Roberto M. Alcohol dependence and withdrawal impair serotonergic regulation of GABA transmission in the rat central nucleus of the amygdala. J Neurosci 2020;40:6842-6853. PMC7470924

 

Kim JS, Martin-Fardon R. Possible role of CRF-Hcrt interaction in the infralimbic cortex in the emergence and maintenance of compulsive alcohol-seeking behavior. Alcohol Clin Exp Res 2020;44:354-367. PMC7018591

 

Kimbrough A, Lurie DJ, Collazo A, Kreifeldt M, Sidhu H, Macedo GC, D'Esposito M, Contet C, George O. Brain-wide functional architecture remodeling by alcohol dependence and abstinence. Proc Natl Acad Sci U S A 2020;117(4):2149-2159. PMC6994986

 

Kirson D, Oleata CS, Roberto M. Taurine suppression of central amygdala GABAergic inhibitory signaling via glycine receptors is disrupted in alcohol dependence. Alcohol Clin Exp Res 2020;44:445-454. PMC7018558

 

Matzeu A, Martin-Fardon R. Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats. Neuropharmacology 2020;164:107906. PMC6954966

 

Matzeu A, Martin-Fardon R. Targeting the orexin system for prescription opioid use disorder. Brain Sci 2020;10(4):226. PMC7225970

 

Okhuarobo A, Bolton JL, Igbe I, Zorrilla EP, Baram TZ, Contet C. A novel mouse model for vulnerability to alcohol dependence induced by early-life adversity. Neurobiol Stress 2020;13:100269. PMC7739069

 

Pavon FJ, Polis I, Stouffer DG, Roberto M, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH, Serrano A. COX-2 inhibition antagonizes intra-accumbens 2-arachidonoylglycerol-mediated reduction in ethanol self-administration in rats. Alcohol Clin Exp Res 2020;44:2158-2165. PMC7680444

 

Simpson S, Shankar K, Kimbrough A, George O. Role of corticotropin-releasing factor in alcohol and nicotine addiction. Brain Res 2020;1740:146850. PMC7869920

 

Spierling S, de Guglielmo G, Kirson D, Kreisler A, Roberto M, George O, Zorrilla EP. Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. Neuropsychopharmacology. 2020;45(4):579-588. PMC7021713.

 

Suárez J, Khom S, Alén F, Natividad LA, Varodayan FP, Patel RR, Kirson D, Arco R, Ballesta A, Bajo M, Rubio L, Martin-Fardon R, Rodríguez de Fonseca F, Roberto M. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addict Biol 2020;25:e12813. PMC8050940

 

Varodayan FP, Minnig MA, Steinman MQ, Oleata CS, Riley MW, Sabino V, Roberto M. PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology 2020;168:107752. PMC7048635

 

Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020;5(3):e131277. PMC7098802.

 

Warden AS, Wolfe SA, Khom S, Varodayan FP, Patel RR, Steinman MQ, Bajo M, Montgomery SE, Vlkolinsky R, Nadav T, Polis I, Roberts AJ, Mayfield RD, Harris RA, Roberto M. Microglia control escalation of drinking in alcohol-dependent mice: genomic and synaptic drivers. Biol Psychiatry 2020;88:910-921. PMC7674270

 

2019

Bajo M, Patel RR, Hedges DM, Varodayan FP, Vlkolinsky R, Davis TD, Burkart MD, Blednov YA, Roberto M. Role of MyD88 in IL-1β and ethanol modulation of GABAergic transmission in the central amygdala. Brain Sci 2019;9(12):E361. PMC6956324

 

de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun  2019;10:1238. PMC6423296

 

Ehlers CL, Gilder DA, Gizer IR, Wilhelmsen KC. Indexing the 'dark side of addiction': substance-induced affective symptoms and alcohol use disorders. Addiction 2019;114(1):139-149. PMC6320236

 

Figueroa AG, Benkwitz C, Surges G, Kunz N, Homanics GE, Pearce RA. Hippocampal β2-GABAA receptors mediate LTP suppression by etomidate and contribute to long-lasting feedback but not feedforward inhibition of pyramidal neurons. J Neurophysiol 2021;126(4):1090-1100. PMC8560413

 

Goulding SP, de Guglielmo G, Carrette LLG, George O, Contet C. Systemic administration of the cyclin-dependent kinase inhibitor (S)-CR8 selectively reduces escalated ethanol intake in dependent rats. Alcohol Clin Exp Res 2019;43:2079-2089. PMC6779498

 

Jimenez VA, Herman MA, Cuzon Carlson VC, Walter NA, Grant KA, Roberto M. Synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys. Neuropsychopharmacology 2019;44:982-993. PMC6461779

 

Mason BJ. Pharmacological treatment of alcohol use disorder. In: Evans, SM (eds) APA Handbook of Psychopharmacology. American Psychological Association, Washington DC, 2019, pp. 481-505.

 

Patel RR, Khom S, Steinman MQ, Varodayan FP, Kiosses WB, Hedges DM, Vlkolinsky R, Nadav T, Polis I, Bajo M, Roberts AJ, Roberto M. IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala. Brain Behav Immun 2019;75:208-219. PMC6383367

 

Pavón FJ, Serrano A, Stouffer DG, Polis I, Roberto M, Cravatt BF, Martin-Fardon R, Rodríguez de Fonseca F, Parsons LH. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice. Addict Biol 2019;24:1204-1215. PMC6551299

 

Roberts AJ, Khom S, Bajo M, Vlkolinsky R, Polis I, Cates-Gatto C, Roberto M, Gruol DL. Increased IL-6 expression in astrocytes is associated with emotionality, alterations in central amygdala GABAergic transmission, and excitability during alcohol withdrawal. Brain Behav Immun 2019;82:188-202. PMC6800653

 

Tunstall BJ, Kirson D, Zallar LJ, McConnell SA, Vendruscolo JCM, Ho CP, Oleata CS, Khom S, Manning M, Lee MR, Leggio L, Koob GF, Roberto M, Vendruscolo LF. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. PLoS Biol 2019;17:e2006421. PMC6467366

 

Wolfe SA, Sidhu H, Patel RR, Kreifeldt M, D'Ambrosio SR, Contet C, Roberto M. Molecular, morphological, and functional characterization of corticotropin-releasing factor receptor 1-expressing neurons in the central nucleus of the amygdala. eNeuro 2019;6: ENEURO.0087-19.2019. PMC6584068

 

Zorrilla EP, Koob GF. Impulsivity derived from the dark side: Neurocircuits that contribute to negative urgency. Front Behav Neurosci 2019;13:136 [corrigendum: 13:188]. PMC6603097

 

Zorrilla EP, Koob GF. The dark side of compulsive eating and food addiction: affective dysregulation, negative reinforcement, and negative urgency. In: Cottone P, Sabino V, Moore CF, Koob GF (eds) Compulsive Eating Behavior and Food Addiction: Emerging Pathological Constructs, Academic Press, New York, 2019, pp. 115-192.

 

2018

Berger AL, Henricks AM, Lugo JM, Wright HR, Warrick CR, Sticht MA, Morena M, Bonilla I, Laredo SA, Craft RM, Parsons LH, Grandes PR, Hillard CJ, Hill MN, McLaughlin RJ. The lateral habenula directs coping styles under conditions of stress via recruitment of the endocannabinoid system. Biol Psychiatry 2018;84(8):611-623. PMC6162143.

 

Blasio A, Wang J, Wang D, Varodayan FP, Pomrenze MB, Miller J, Lee AM, McMahon T, Gyawali S, Wang HY, Roberto M, McHardy S, Pleiss MA, Messing RO. Novel small-molecule inhibitors of protein kinase C epsilon reduce ethanol consumption in mice. Biol Psychiatry 2018;84:193-201. PMC5984071 

 

Ehlers CL, Wills D, Gilder DA. A history of binge drinking during adolescence is associated with poorer sleep quality in young adult Mexican Americans and American Indians. Psychopharmacology 2018;235(6):1775-1782. PMC6013062
de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O. Inhibition of glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. Pharmacol Biochem Behav 2018;167:36-41. PMC5866249 

 

Fannon MJ, Mysore KK, Williams J, Quach LW, Purohit DC, Sibley BD, Sage-Sepulveda JS, Kharidia KM, Morales Silva RJ, Terranova MJ, Somkuwar SS, Staples MC, Mandyam CD. Hippocampal neural progenitor cells play a distinct role in fear memory retrieval in male and female CIE rats. Neuropharmacology 2018;143:239-249. PMC6269203

 

Kirson D, Oleata CS, Parsons LH, Ciccocioppo R, Roberto M. CB1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats. Addict Biol 2018;23:676-688. PMC5745318 

 

Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O. Systemic and intra-habenular activation of the orphan G protein-coupled receptor GPR139 decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rats. eNeuro 2018;5:ENEURO.0153-18.2018. PMC6027959

 

Kreisler AD, Mattock M, Zorrilla EP. The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats. Appetite 2018;130:59-69. PMC6168430

 

Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP. Evaluation of alcohol preference and drinking in msP rats bearing a Crhr1 promoter polymorphism. Front Psychiatry 2018;9:28. PMC5818434

 

Mason BJ, Quello S, Shadan F. Gabapentin for the treatment of alcohol use disorder. Expert Opin Investig Drugs 2018;27:113-124. PMC5957503

 

Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R. Dynorphin counteracts orexin in the paraventricular nucleus of the thalamus: cellular and behavioral evidence. Neuropsychopharmacology 2018;43:1010-1020. PMC5854806

 

Matzeu A, Martin-Fardon R. Drug seeking and relapse: new evidence of a role for orexin and dynorphin co-transmission in the paraventricular nucleus of the thalamus. Front Neurol 2018;9:720. PMC6121102 

 

Matzeu A, Terenius L, Martin-Fardon R. Exploring sex differences in the attenuation of ethanol drinking by naltrexone in dependent rats during early and protracted abstinence. Alcohol Clin Exp Res 2018;42:2466-2478. PMC6286204

 

McClatchy DB, Yu NK, Martínez-Bartolomé S, Patel R, Pelletier AR, Lavalle-Adam M, Powell SB, Roberto M, Yates JR. Structural analysis of hippocampal kinase signal transduction. ACS Chem Neurosci 2018;9:3072-3085. PMC6374210

 

Natividad LA, Steinman MQ, Laredo SA, Irimia C, Polis I, Lintz R, Buczynski MW, Martin-Fardon R, Roberto M, Parsons LH. Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility. Addict Biol 2018;23:1117-1129. PMC5862723

 

Roberto M, Patel RR, Bajo M. Ethanol and cytokines in the central nervous system. Handb Exp Pharmacol 2018;248:397-431. PMC7886012

 

Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. Neuropsychopharmacology 2018;43:1840-1850. PMC6046053 

 

Sidhu H, Kreifeldt M, Contet C. Affective disturbances during withdrawal from chronic intermittent ethanol inhalation in C57BL/6J and DBA/2J male mice. Alcohol Clin Exp Res 2018;42:1281-1290. PMC6028290

 

Spierling SR, Kreisler AD, Williams CA, Fang SY, Pucci SN, Kines KT, Zorrilla EP. Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: sex differences and individual vulnerability. Physiol Behav 2018;192:3-16. PMC6019212

 

Varodayan FP, Khom S, Patel R, Hedges D, Steinman MQ, Oleata CS, Roberto M, Bajo M. Role of TLR4 in the modulation of central amygdala GABA transmission by CRF following restraint stress. Alcohol Alcohol 2018;53:642-649. PMC6203127

 

Varodayan FP, Sidhu H, Kreifeldt M, Roberto M, Contet C. Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal. Neuropharmacology 2018;133:470-480. PMC5865397